Liquid-filled hard capsules provide a versatile alternative to traditional solid oral dosage forms, offering advantages such as streamlined manufacturing, scalable production, rapid drug absorption, and improved product protection. Liquid filling enables precise control of valuable research compounds that may be available only in limited quantities, helping reduce material waste during development.
Because these capsules often require fewer excipients than tablets or other solid forms, they support faster formulation timelines and simplified development pathways. Liquid-filled hard capsules are particularly well-suited for compounds with formulation challenges, including low-dose products, poorly soluble molecules, and highly potent active pharmaceutical ingredients.
Our integrated contract development and research capabilities support your molecule from early formulation through clinical supply manufacturing and commercial production.
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Liquid-filled hard capsules offer multiple formulation and performance advantages across various stages of pharmaceutical development.
Delivering the active ingredient in solution or suspension can significantly enhance absorption for compounds with limited water solubility.
Formulating low-melting-point compounds as liquids eliminates challenges associated with solid handling and compression.
Liquid encapsulation minimizes powder exposure and reduces the risk of cross-contamination, improving operator safety during manufacturing.
Hard-shell capsules provide protection from environmental moisture, supporting long-term dosage form stability.
Capsule shell composition and internal formulation can be tailored to achieve specific dissolution and release profiles.
Liquid-filled capsules do not require binders, lubricants, or plasticizers commonly used in tablets and softgels, supporting lean formulation design.
Unlike softgels, hard capsules can incorporate liquids alongside beads, pellets, or mini-tablets for advanced combination therapies.
Sealed and banded capsules create a secure, non-permeable dosage form.
Liquid-filled hard capsules make manipulation, injection, or inhalation more difficult, supporting abuse-deterrent strategies.
Thinner capsule walls allow for smaller dosage sizes and faster, more complete dissolution.
A wide selection of capsule and banding color combinations enables strong visual differentiation and product identity.
Learn how liquid-filled hard capsules can streamline development timelines and support efficient progression to the clinic.
A long-standing industry standard, gelatin capsules offer reliable performance and compatibility with high-speed filling and sealing operations. They support self-suspending mixture formulations at elevated temperatures and accommodate excipients designed to improve the bioavailability of challenging compounds.
Hypromellose capsules deliver consistent pharmaceutical performance while meeting global compendial requirements. They are compatible with a broad range of excipients, perform exceptionally well in low-humidity environments, and maintain mechanical integrity at reduced moisture levels. These capsules are ideal for innovative drug development programs and can support higher processing temperatures.
Enteric capsule solutions protect active ingredients from gastric degradation and enable targeted release in the intestinal environment. By eliminating the need for additional enteric coating steps, these capsules simplify manufacturing while improving control over delayed-release performance.